Sodium Hydroxide → HCID 19068157, 화합물

HRID 1957577노트

반응식

HRID 1957577 반응식
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:22]=[C:21]([C:23]([O:25]C)=[O:24])[O:20][N:19]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[OH-].[Na+]>CO>[C:1]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][CH2:15][CH2:16][O:17][C:18]2[CH:22]=[C:21]([C:23]([OH:25])=[O:24])[O:20][N:19]=2)[CH2:12][CH2:13]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 19068171HCID 19068171, 화합물

생성물 1

HCID 19068157HCID 19068157, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 3-6 (580 mg, 1.6 mmol), 1N NaOH (3.1 mL, 3.1 mmol), and CH3OH (8 mL) was stirred at ambient temperature for 1.0 h. The reaction was then concentrated and the resulting gum acidified with 1M NaHSO4. The aqueous layer was saturated with NaCl and then extracted with ether. The extracts were combined, dried (MgSO4) and concentrated to give 3-7 as a viscous gum. Rf 0.20 (silica, 9/0.5/0.5 CH2Cl2/CH3OH/HOAc).

후처리

  1. concentrationThe reaction was then concentrated
  2. extractionextracted with ether
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9f21d1109f1642879f64c6683b606e68
출처 데이터셋
uspto-grants-1998_07
특허 번호
US05786373

반응 노트

불러오는 중…