Lithium Hydroxide → HCID 59363504, 화합물

HRID 1957929노트

반응식

HRID 1957929 반응식
[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=2)=[O:9])[CH:4]=[C:3]1[C:22]([O:24]CC)=[O:23].[OH-].[Li+]>C1COCC1.O>[CH3:1][N:2]1[CH:6]=[C:5]([NH:7][C:8]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([O:17][C:18]([F:20])([F:21])[F:19])=[CH:15][CH:16]=2)=[O:9])[CH:4]=[C:3]1[C:22]([OH:24])=[O:23]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 59363501HCID 59363501, 화합물

생성물 1

HCID 59363504HCID 59363504, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

470 mg (1.27 mmol) of ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-pyrrole-2-carboxylate are initially charged in 5 ml of THF, 152 mg (6.33 mmol) of lithium hydroxide in 1 ml of water are added and the mixture is stirred under reflux overnight. The reaction mixture is concentrated, the residue is acidified with 2M hydrochloric acid and the precipitate formed is filtered off with suction and dried under reduced pressure. This gives a solid.

후처리

  1. temperatureunder reflux overnight
  2. concentrationThe reaction mixture is concentrated
  3. customthe precipitate formed
  4. filtrationis filtered off with suction
  5. customdried under reduced pressure
  6. customThis gives a solid

출처 및 근거

ORD 기록
ord-ca89fc13e2a14b1f8278ccb967f19dcb
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410090B2

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