N-bromobutanimide → HCID 67125220, 화합물

HRID 1958084노트

반응식

HRID 1958084 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][N:11]=[C:10]([CH3:19])[N:9]=1.[Br:20]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl>[Br:20][CH2:19][C:10]1[N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][N:11]=1

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 18981952Ethyl 4-(2-chlorophenyl)-2-methylpyrimidine-5-carboxylate

생성물 1

HCID 67125220HCID 67125220, 화합물

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

An amount of 820 mg (2.96 mmol) of ethyl 4-(2-chlorophenyl)-2-methylpyrimidine-5-carboxylate and 633 mg (3.55 mmol) of N-bromosuccinimide were dissolved in 18 ml of carbon tetrachloride and heated with stirring to boiling. At the heat of boiling, in portions, 49 mg (0.29 mmol) of 2,2′-azobis-2-methylpropanenitrile were added over 5 hours, followed by refluxing for a further hour. After cooling to room temperature, the reaction solution was filtered and the mother liquor was freed from the solvent under reduced pressure. The desired product was isolated by chromatographic purification.

후처리

  1. temperatureheated
  2. temperatureAt the heat
  3. additionwere added over 5 hours
  4. temperatureby refluxing for a further hour
  5. filtrationthe reaction solution was filtered

출처 및 근거

ORD 기록
ord-cc4bbd6aafed4497bed39242722ecd9e
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410106B2

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