Chloroacetaldehyde → 6-broMo-8-hydroxy-iMidazo[1,2-a] pyridine hydrochloride

HRID 1958495노트

반응식

HRID 1958495 반응식
[NH2:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([Br:9])=[CH:4][N:3]=1.[Cl:10][CH2:11][CH:12]=O>CCO>[ClH:10].[Br:9][C:5]1[CH:6]=[C:7]([OH:8])[C:2]2[N:3]([CH:11]=[CH:12][N:1]=2)[CH:4]=1

참가 물질

4

반응물 2

HCID 33ChloroacetaldehydeHCID 116940412-Amino-5-bromo-3-hydroxypyridine

생성물 1

HCID 670075396-broMo-8-hydroxy-iMidazo[1,2-a] pyridine hydrochloride수율 93.1%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

2-Amino-3-hydroxy-5-bromopyridine (Heterocycles, 1995, 41, 2799) (124 mg, 0.65 mmol) was dissolved in EtOH (3 mL) and added chloroacetaldehyde (0.2 mL, 1.3 mmol, 50% in water) and the resulting solution heated at 60° C. overnight. The solvents were then removed and the solids were crystallized from acetone to give 6-bromoimidazo[1,2-a]pyridin-8-ol hydrochloride (151 mg, 92%).

후처리

  1. customThe solvents were then removed
  2. customthe solids were crystallized from acetone

출처 및 근거

ORD 기록
ord-26da30496a174d878adf1c01f2244cbd
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410128B2

반응 노트

불러오는 중…