Methyl iodide → (R)-4-(benzyloxy)-N,N,N-trimethyl-4-oxo-2-(6-phenoxypyridine-3-sulfonamido)butan-1-aminium iodide

HRID 1958718노트

반응식

HRID 1958718 반응식
[CH3:1][N:2]([CH3:33])[CH2:3][C@H:4]([NH:16][S:17]([C:20]1[CH:21]=[N:22][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:24][CH:25]=1)(=[O:19])=[O:18])[CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[CH3:34][I:35]>C(Cl)Cl>[I-:35].[CH2:9]([O:8][C:6](=[O:7])[CH2:5][C@@H:4]([NH:16][S:17]([C:20]1[CH:21]=[N:22][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:24][CH:25]=1)(=[O:19])=[O:18])[CH2:3][N+:2]([CH3:34])([CH3:1])[CH3:33])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 86641216(R)-benzyl 4-(dimethylamino)-3-(6-phenoxypyridine-3-sulfonamido)butanoate

생성물 1

HCID 68742884(R)-4-(benzyloxy)-N,N,N-trimethyl-4-oxo-2-(6-phenoxypyridine-3-sulfonamido)butan-1-aminium iodide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of (R)-benzyl 4-(dimethylamino)-3-(6-phenoxypyridine-3-sulfonamido)butanoate in CH2Cl2 (2 mL) was added methyl iodide (100 pit). The reaction was stirred overnight and concentrated to dryness to give the title compound in quantitative yield. 1H NMR (400 MHz, CDCl3) δ ppm 8.63 (s, 1H), 8.26 (d, J=8.8 Hz, 1H), 7.43 (t, J=7.7 Hz, 2H), 7.39-7.29 (m, 5H), 7.13 (d, J=8.1 Hz, 2H), 6.99 (d, 1H, J=8.8 Hz, 1H) 5.14-5.03 (m, 2H), 4.49-4.41 (m, 1H), 4.36-4.30 (m, 1H), 3.74-3.71 (m, 1H), 3.42 (s, 9H), 2.91-2.84 (m, 1H), 2.46-2.42 (m, 1H).

후처리

  1. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-ccabe881a5464c4a83200492ddf804ef
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410150B2

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