[CH3:1][N:2]([CH3:35])[CH2:3][C@H:4]([NH:16][S:17]([C:20]1[S:21][C:22]([C:25]2[N:29]([CH3:30])[N:28]=[C:27]([C:31]([F:34])([F:33])[F:32])[CH:26]=2)=[CH:23][CH:24]=1)(=[O:19])=[O:18])[CH2:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[CH3:36][I:37]>C(Cl)Cl>[I-:37].[CH2:9]([O:8][C:6](=[O:7])[CH2:5][C@@H:4]([NH:16][S:17]([C:20]1[S:21][C:22]([C:25]2[N:29]([CH3:30])[N:28]=[C:27]([C:31]([F:34])([F:32])[F:33])[CH:26]=2)=[CH:23][CH:24]=1)(=[O:18])=[O:19])[CH2:3][N+:2]([CH3:36])([CH3:1])[CH3:35])[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1To a solution of (R)-benzyl 4-(dimethylamino)-3-(5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)thiophene-2-sulfonamido)butanoate in CH2Cl2 (2 mL) was added methyl iodide (100 μL). The reaction was stirred overnight and concentrated to dryness to give the title compound in quantitative yield.
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