Hydrochloric Acid → HCID 66744467, 화합물

HRID 1959422노트

반응식

HRID 1959422 반응식
[C:1]([N:5]1[CH2:9][C:8]2([CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH2:7][CH2:6]1)(=[O:4])[CH2:2][CH3:3].Cl>C(Cl)Cl.O1CCOCC1>[CH2:7]1[C:8]2([CH2:13][CH2:12][NH:11][CH2:10]2)[CH2:9][N:5]([C:1](=[O:4])[CH2:2][CH3:3])[CH2:6]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 66745092Tert-butyl 7-propionyl-2,7-diazaspiro[4.4]nonane-2-carboxylate

생성물 1

HCID 66744467HCID 66744467, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of tert-butyl 3-propanoyl-3,7-diazaspiro[4.4]nonane-7-carboxylate (153 mg, 0.54 mmol) in DCM (0.5 mL) was added a solution of hydrogen chloride (1.4 mL of 4 M, 5.4 mmol) in dioxane. The reaction mixture was stirred at room temperature for 1 h. The solvents were removed under reduced pressure and the crude product was dried on the high vacuum for 1 h to yield 1-(3,7-diazaspiro[4.4]nonan-3-yl)propan-1-one as an off white gum. LC/MS m/z 183.3 [M+H]+.

후처리

  1. customThe solvents were removed under reduced pressure
  2. dry with materialthe crude product was dried on the high vacuum for 1 h

출처 및 근거

ORD 기록
ord-5e23ce4042914834b5c54c59d1543f0c
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410112B2

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