Bromine → 2-Amino-1,3-benzothiazole-7-carboxylic acid

HRID 1959792노트

반응식

HRID 1959792 반응식
[NH:1]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])[C:2]([NH2:4])=[S:3].BrBr>C(Cl)(Cl)Cl>[NH2:4][C:2]1[S:3][C:6]2[C:7]([C:8]([OH:10])=[O:9])=[CH:11][CH:12]=[CH:13][C:5]=2[N:1]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 8205751-(3-Carboxyphenyl)-2-thiourea

생성물 1

HCID 202855902-Amino-1,3-benzothiazole-7-carboxylic acid수율 98%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a suspension of 3-thioureidobenzoic acid (1.06 g, 5.41 mmol) in chloroform (25 mL) was added a solution of bromine (0.4 mL, 8.0 mmol) dropwise at room temperature. The resulting mixture was heated under reflux for 3 hrs and allowed to stir at room temperature for 60 hrs. The solvent was evaporated, water was added and the resulting solids were isolated by filtration. The crude product was washed with water and dried to yield 1.03 g (98%) of the title compound as a gray solid.

후처리

  1. temperatureThe resulting mixture was heated
  2. temperatureunder reflux for 3 hrs
  3. customThe solvent was evaporated
  4. additionwater was added
  5. customthe resulting solids were isolated by filtration
  6. washThe crude product was washed with water
  7. customdried

출처 및 근거

ORD 기록
ord-d3edf496817045ab9b044d97f53fa9e3
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08410272B2

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