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Hydrochloric Acid → {[2-(2-{7-[methyl(2-thienylsulfonyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)ethyl]thio}acetic acid

HRID 1960518
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인쇄 미리보기

반응식

HRID 1960518 반응식
C([O:3][C:4](=[O:33])[CH2:5][S:6][CH2:7][CH2:8][CH:9]1[S:13][C:12]([C:14]2[NH:15][C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[N:23]([CH3:32])[S:24]([C:27]2[S:28][CH:29]=[CH:30][CH:31]=2)(=[O:26])=[O:25])=[N:11][CH2:10]1)C.[OH-].[K+].Cl>O1CCCC1.CO.O>[CH3:32][N:23]([S:24]([C:27]1[S:28][CH:29]=[CH:30][CH:31]=1)(=[O:26])=[O:25])[C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:16]=1[NH:15][C:14]([C:12]1[S:13][CH:9]([CH2:8][CH2:7][S:6][CH2:5][C:4]([OH:33])=[O:3])[CH2:10][N:11]=1)=[CH:22]2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59136154ethyl{[2-(2-{7-[methyl(2-thienylsulfonyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)ethyl]thio}acetate

생성물 1

HCID 59135892{[2-(2-{7-[methyl(2-thienylsulfonyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)ethyl]thio}acetic acid수율 61.6%

시약·촉매·용매 3

HCID 887
Methanol
용매
HCID 962Water용매
HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of ethyl{[2-(2-{7-[methyl(2-thienylsulfonyl)amino]-1H-indol-2-yl}-4,5-dihydro-1,3-thiazol-5-yl)ethyl]thio}acetate (60 mg) in tetrahydrofuran (2 mL) and methanol (2 mL) was added, under ice-cooling, a solution prepared by dissolving potassium hydroxide (purity 85%, 20 mg) in water (0.5 mL). The reaction mixture was allowed to warm to room temperature, and stirred for 1 hr. 1M Hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and saturated brine, dried (MgSO4), and concentrated. The residue was recrystallized from a mixed solvent of ethyl acetate-hexane to give the title compound (35 mg, yield 61%) as white crystals. MS:496(MH+).

후처리

  1. temperaturecooling
  2. customa solution prepared
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe ethyl acetate layer was washed with water and saturated brine
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated
  7. customThe residue was recrystallized from a mixed solvent of ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-86b9330cb7364c458307e4e02079de15
출처 데이터셋
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08410087B2

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