Thiosemicarbazide → HCID 178527901, 화합물
반응식
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[CH:11]=[CH:12]OC)=[CH:4][CH:3]=1.[NH2:17][NH:18][C:19]([NH2:21])=[S:20]>CO>[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:21][C:19](=[S:20])[N:18]3[N:17]=[CH:12][CH:11]=[C:10]3[CH:9]=2)=[CH:4][CH:3]=1참가 물질
4
실험 절차
A mixture of 1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione (compound F1)(1.9 g) and thiosemicarbazide (5 g) in methanol (220 ml) is heated to reflux temperature. After the reaction is completed the solid is filtered and washed with methanol. The filtrate with the product is purified by flash silica gel chromatography.
후처리
- temperatureis heated
- temperatureto reflux temperature
- filtrationis filtered
- washwashed with methanol
- customThe filtrate with the product is purified by flash silica gel chromatography
출처 및 근거
- ORD 기록
- ord-1a283ebeecc94dc18563be03e16f73f1
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745446B2
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