4-Fluoro-3-(trifluoromethyl)benzonitrile → 4-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile

HRID 1961427

반응식

HRID 1961427 반응식
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[CH3:14][S:15]([O-:17])=[O:16].[Na+]>CS(C)=O.O>[CH3:14][S:15]([C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11])(=[O:17])=[O:16]

참가 물질

5

반응물 2

HCID 1442554-Fluoro-3-(trifluoromethyl)benzonitrileHCID 2733271Sodium methanesulfinate

생성물 1

HCID 459337164-(Methylsulfonyl)-3-(trifluoromethyl)benzonitrile

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

4-Fluoro-3-(trifluoromethyl)benzonitrile (400 mg, 2.12 mmol) was suspended together with sodium methanesulfinate (216 mg, 2.12 mmol) in DMSO (2 ml) and stirred at 80° C. for 22 hours. The reaction was then cooled, diluted with 25 ml H2O and filtered. Filtered solids were evaporated from toluene to give 536 mg of the title substance (quant).

후처리

  1. temperatureThe reaction was then cooled
  2. filtrationfiltered
  3. filtrationFiltered solids
  4. customwere evaporated from toluene
  5. customto give 536 mg of the title substance (quant)

출처 및 근거

ORD 기록
ord-25131b47e8044a0abb5bb5e600f8a7d5
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415333B2

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