Sodium Hydroxide → 2-(Methylamino)-1,8-naphthyridine-3-carboxylic acid

HRID 1961448노트

반응식

HRID 1961448 반응식
[CH3:1][NH:2][C:3]1[C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[OH-].[Na+]>CCO>[CH3:1][NH:2][C:3]1[C:12]([C:13]([OH:15])=[O:14])=[CH:11][C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 66745462Ethyl 2-(methylamino)-1,8-naphthyridine-3-carboxylate

생성물 1

HCID 666337022-(Methylamino)-1,8-naphthyridine-3-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

Ethyl 2-(methylamino)-1,8-naphthyridine-3-carboxylate (58 mg, 0.25 mmol) was dissolved in EtOH. NaOH (0.75 ml, 1M aqueous solution) was added to the solution and the mixture stirred at 40° C. for 5.0 h. The organic solvent was removed under vacuo. The remaining aqueous residue was treated with HCl (1M aqueous solution) until slightly acidic and the product extracted with EtOAc. The combined organic phases were dried over MgSO4, filtered and concentrated yielding 50.0 mg (quant) of the title compound.

후처리

  1. customThe organic solvent was removed under vacuo
  2. additionThe remaining aqueous residue was treated with HCl (1M aqueous solution) until slightly acidic and the product
  3. extractionextracted with EtOAc
  4. dry with materialThe combined organic phases were dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-88513ff0f3f642b6af055c6c60df398f
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415333B2

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