N-(4-tert-butyl-2-hydroxybenzyl)-2-chloroacetamide → 2-Aminomethyl-5-tert-butylphenol hydrochloride

HRID 1961490노트

반응식

HRID 1961490 반응식
[C:1]([C:5]1[CH:16]=[CH:15][C:8]([CH2:9][NH:10]C(=O)C[Cl:13])=[C:7]([OH:17])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CCO.Cl>[ClH:13].[NH2:10][CH2:9][C:8]1[CH:15]=[CH:16][C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])=[CH:6][C:7]=1[OH:17]

참가 물질

4

반응물 1

HCID 66746309N-(4-tert-butyl-2-hydroxybenzyl)-2-chloroacetamide

생성물 1

HCID 98157872-Aminomethyl-5-tert-butylphenol hydrochloride수율 98.4%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매

반응 조건

온도
85 °C

실험 절차

N-(4-tert-Butyl-2-hydroxybenzyl)-2-chloroacetamide (270.0 mg, 1.06 mmol) was dissolved in a mixture of EtOH (4.0 ml) and conc. HCl (1.3 ml). The mixture was stirred at 85° C. for 3.0 h. The solvents were removed under vacuum to afford 225 mg (98%) of the title compound.

후처리

  1. customThe solvents were removed under vacuum

출처 및 근거

ORD 기록
ord-5cb7005112394fe3a53e0b87f0577507
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415333B2

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