Pyridine → N-(4-chloro-3-nitrophenyl)methanesulfonamide

HRID 1962299

반응식

HRID 1962299 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[CH3:12][S:13](Cl)(=[O:15])=[O:14].N1C=CC=CC=1>C1COCC1.Cl>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][S:13]([CH3:12])(=[O:15])=[O:14])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

참가 물질

6

반응물 3

HCID 1049PyridineHCID 124774-Chloro-3-nitroanilineHCID 31297Methanesulfonyl chloride

생성물 1

HCID 3755760N-(4-chloro-3-nitrophenyl)methanesulfonamide수율 92.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 4-chloro-3-nitroaniline (5.0 g, 29 mmol), methanesulfonyl chloride (2.37 mL, 30.4 mmol) and pyridine (5.9 mL, 72.4 mmol) in THF (100 mL) was stirred for 24 h. Poured in 1M HCl (500 mL). The resulting precipitate was filtered and air-dried to provide the title compound as a solid (6.7 g, 92%).

후처리

  1. filtrationThe resulting precipitate was filtered
  2. customair-dried

출처 및 근거

ORD 기록
ord-61cf93d8f73b4f88bedce21cb30599fb
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415351B2

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