Sodium Cyanide → 4-Amino-1-methoxy-piperidine-4-carbonitrile

HRID 1962357

반응식

HRID 1962357 반응식
[CH3:1][O:2][N:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.[Cl-].[NH4+:11].[C-:12]#[N:13].[Na+]>[OH-].[NH4+].O>[NH2:11][C:6]1([C:12]#[N:13])[CH2:7][CH2:8][N:3]([O:2][CH3:1])[CH2:4][CH2:5]1

참가 물질

6

반응물 3

HCID 8929Sodium CyanideHCID 25517Ammonium ChlorideHCID 199366531-Methoxypiperidin-4-one

생성물 1

HCID 596145944-Amino-1-methoxy-piperidine-4-carbonitrile수율 68.7%

시약·촉매·용매 2

HCID 962Water용매HCID 14923Ammonium Hydroxide용매

반응 조건

온도
25 °C

실험 절차

To 10 g of N-methoxy-4-piperidone (Journal of Organic Chemistry (1961), 26, 1867-74) in 240 ml of ammonium hydroxide (25% in water) was added 6.2 g of ammonium chloride and 4.6 g of sodium cyanide. After stirring for 18 hours at 25° C. the reaction mixture was diluted with 200 ml of water and extracted with ethyl acetate. The organic phase was separated, dried over sodium sulfate and evaporated. 8.25 g of 4-amino-1-methoxy-piperidine-4-carbonitrile was obtained as a light brown oil, which was used without further purification in the next step.

후처리

  1. extractionextracted with ethyl acetate
  2. customThe organic phase was separated
  3. dry with materialdried over sodium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-6f889f405fcb447ab51798719fd853e6
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415369B2

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