Sodium Hydroxide → (5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid

HRID 1962368노트

반응식

HRID 1962368 반응식
C[O:2][C:3](=[O:16])[CH2:4][C:5]1[CH:10]=[C:9]([CH:11]2[CH2:13][CH2:12]2)[C:8]([CH3:14])=[CH:7][C:6]=1[CH3:15].[OH-].[Na+]>CO>[CH:11]1([C:9]2[C:8]([CH3:14])=[CH:7][C:6]([CH3:15])=[C:5]([CH2:4][C:3]([OH:16])=[O:2])[CH:10]=2)[CH2:12][CH2:13]1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 59614579(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester

생성물 1

HCID 59614593(5-Cyclopropyl-2,4-dimethyl-phenyl)-acetic acid수율 98.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2.5 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid methyl ester in 30 ml of methanol was kept at ice bath temperature and treated with 0.5 g of sodium hydroxide in 5 portions. The reaction mixture was stirred at room temperature for 1.5 hours. The solvent was removed in vacuo, the residue poured into water and extracted with diethyl ether. The combined organic phases were dried with sodium sulfate, filtered and concentrated to afford 2.3 g of (5-cyclopropyl-2,4-dimethyl-phenyl)-acetic acid.

후처리

  1. customThe solvent was removed in vacuo
  2. additionthe residue poured into water
  3. extractionextracted with diethyl ether
  4. dry with materialThe combined organic phases were dried with sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ccc0ac7a637f4331bd30443462201ccb
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415369B2

반응 노트

불러오는 중…