Hydrochloride methanol → Hydrochloric Acid

HRID 1962422노트

반응식

HRID 1962422 반응식
C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:28].CO>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:27])=[CH:20][N:21]=[CH:22][C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:28]

참가 물질

4

반응물 2

HCID 21893726Hydrochloride methanolHCID 67242852(S)-3-(tert-Butoxycarbonylamino)-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

생성물 2

HCID 313Hydrochloric AcidHCID 16223985(S)-3-Amino-1-(4-bromo-5-isoquinolinesulfonyl)pyrrolidine

실험 절차

Intermediate 1a (120 mg) prepared in Step A mentioned above was added with 10% hydrogen chloride/methanol (2 ml, Tokyo Kasei Kogyo), and the mixture was stirred at room temperature for 12 hours. The solvent was concentrated under reduced pressure, and the obtained solid was collected by filtration to obtain the title compound as hydrochloride (84 mg).

후처리

  1. concentrationThe solvent was concentrated under reduced pressure
  2. filtrationthe obtained solid was collected by filtration

출처 및 근거

ORD 기록
ord-334c021098a8453baa66a3bfdf772bbb
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415372B2

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