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3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → Hydrochloric Acid

HRID 1962448
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HRID 1962448 반응식
C(O[C:6]([N:8]([CH:10]1[CH2:14][CH2:13][N:12]([S:15]([C:18]2[C:19]3[C:20]([Cl:28])=[CH:21][N:22]=[CH:23][C:24]=3[CH:25]=[CH:26][CH:27]=2)(=[O:17])=[O:16])[CH2:11]1)C)=O)(C)(C)C.[Cl:29]C1C2C(S(Cl)(=O)=O)=CC=CC=2C=NC=1.C(OC(N(C1CCNC1)C)=O)(C)(C)C.BrC1C2C(S(Cl)(=O)=O)=CC=CC=2C=NC=1.C(OC(N([C@H]1CCNC1)C)=O)(C)(C)C>>[Cl:28][C:20]1[C:19]2[C:18]([S:15]([N:12]3[CH2:13][CH2:14][CH:10]([NH:8][CH3:6])[CH2:11]3)(=[O:16])=[O:17])=[CH:27][CH:26]=[CH:25][C:24]=2[CH:23]=[N:22][CH:21]=1.[ClH:29]
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참가 물질

7

반응물 5

HCID 27614043-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidineHCID 7171888(S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl esterHCID 145800584-Bromo-5-isoquinolinesulfonyl chlorideHCID 221219084-Chloroisoquinoline-5-sulfonyl chlorideHCID 672427483-[n-(Tert-butoxycarbonyl)-n-methylamino]-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine2회

생성물 2

HCID 313Hydrochloric Acid
HCID 67203512(r/s)-1-(4-Chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine

실험 절차

3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 21) can be prepared by using 4-chloro-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine in the method of Example 1-3, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methyl-amino]pyrrolidine, respectively, and then used in the method of Example 1-3, Step B in a similar manner to obtain the title compound as hydrochloride.

출처 및 근거

ORD 기록
ord-8f685e7d092c445787ab0e0564d01062
출처 데이터셋
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08415372B2

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