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(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine → Hydrochloric Acid

HRID 1962470
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인쇄 미리보기

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HRID 1962470 반응식
C(OC([NH:8][C@@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:28])=[CH:20][N:21]=[C:22]([Cl:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.C(OC([NH:36][C@@H]1CCNC1)=O)(C)(C)C.C(OC(N([C@H]1CCNC1)C)=O)(C)(C)C>>[NH2:8][C@@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Br:28])=[CH:20][N:21]=[C:22]([NH2:36])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1.[ClH:27]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 1514397(3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidineHCID 7171888(S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl esterHCID 86627811(R)-3-(tert-Butoxycarbonylamino)-1-(1-chloro-4-bromo-5-isoquinolinesulfonyl)pyrrolidine

생성물 2

HCID 313Hydrochloric AcidHCID 67243451(R)-3-Amino-1-(1-amino-4-bromo-5-isoquinolinesulfonyl)pyrrolidine

실험 절차

(R)-3-(tert-Butoxycarbonylamino)-1-(1-chloro-4-bromo-5-isoquinoline-sulfonyl)pyrrolidine can be prepared by using (R)-3-(tert-butoxycarbonylamino)-pyrrolidine in the method of Example 35-1, Step A instead of (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, and then the protective group of the obtained compound can be removed according to the method described in Example 39-1, Step B to obtain the title compound as hydrochloride.

후처리

  1. customthe protective group of the obtained compound can be removed

출처 및 근거

ORD 기록
ord-b311619ec5184b9999a11cb6496c17c9
출처 데이터셋
uspto-grants-2013_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08415372B2

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