Hydrochloric Acid → 2-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol

HRID 1962875노트

반응식

HRID 1962875 반응식
[CH3:1][C:2]1([CH2:12][O:13]CC#C)[NH:6][C:5]2(CCC[CH2:8][CH2:7]2)[O:4][CH2:3]1.Cl>O>[NH2:6][C:2]([CH3:1])([CH2:3][O:4][CH2:5][C:7]#[CH:8])[CH2:12][OH:13]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 595654083-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane

생성물 1

HCID 595653842-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol수율 102.7%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

3-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane (1.83 g) in an aqueous solution of HCl (6N) (2.73 ml) were refluxed for 1 hr. The reaction mixture was cooled down to room temperature, diluted with water and extracted thrice with ethyl ether. The two layers were separated. The aqueous layer was concentrated under reduced pressure to yield 2-amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol hydrochloric salt (1.205 g) as a white beige solid which was used as such in Stage 3 described below. 1H NMR (DMSO) δ ppm: 8.02 (3H, s br); 5.47 (1H, s br); 4.21 (2H, s); 3.54-3.49 (5H, m); 1.15 (3H, s).

후처리

  1. extractionextracted thrice with ethyl ether
  2. customThe two layers were separated
  3. concentrationThe aqueous layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ae3bb24121ea4854a6d21cbb4a62e16d
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415272B2

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