Methyl 2-(2,4-difluorophenyl)isonicotinate hydrochloride → Methyl 2-(2,4-difluorophenyl)piperidine-4-carboxylate hydrochloride

HRID 1963170노트

반응식

HRID 1963170 반응식
[ClH:1].[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[C:10]1[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=1)[C:13]([O:15][CH3:16])=[O:14]>CO.[Pt](=O)=O>[ClH:1].[F:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[CH:10]1[CH2:11][CH:12]([C:13]([O:15][CH3:16])=[O:14])[CH2:17][CH2:18][NH:19]1

참가 물질

4

반응물 1

HCID 66731571Methyl 2-(2,4-difluorophenyl)isonicotinate hydrochloride

생성물 1

HCID 66731925Methyl 2-(2,4-difluorophenyl)piperidine-4-carboxylate hydrochloride수율 58.3%

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

Methyl 2-(2,4-difluorophenyl)isonicotinate hydrochloride (3.93 g, 13.76 mmol) was dissolved in MeOH (40 mL) and platinum(IV) oxide (0.312 g, 1.38 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 2 h. The catalyst was filtered off, washed with MeOH and the eluate evaporated leaving methyl 2-(2,4-difluorophenyl)piperidine-4-carboxylate hydrochloride (2.34 g, 58%) as a slightly yellow solid. MS m/z 256 (M+H)+

후처리

  1. customwas hydrogenated in a Büchi hydrogenator at room temperature
  2. filtrationThe catalyst was filtered off
  3. washwashed with MeOH
  4. customthe eluate evaporated

출처 및 근거

ORD 기록
ord-693db4c5c9994e1eb734df785919ad95
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08415378B2

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