N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide → N,N-dimethyl-2-[methyl-(2-piperidin-4-yl-ethyl)-amino]-acetamide

HRID 1965945노트

반응식

HRID 1965945 반응식
[CH3:1][N:2]([CH3:16])[C:3](=[O:15])[CH2:4][N:5]([CH3:14])[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1>C(O)(=O)C.CCOCC.O=[Pt]=O>[CH3:16][N:2]([CH3:1])[C:3](=[O:15])[CH2:4][N:5]([CH3:14])[CH2:6][CH2:7][CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1

참가 물질

5

반응물 1

HCID 21081298N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide

생성물 1

HCID 21081297N,N-dimethyl-2-[methyl-(2-piperidin-4-yl-ethyl)-amino]-acetamide

시약·촉매·용매 3

HCID 345198Adams' catalyst촉매HCID 176Acetic Acid용매HCID 3283Diethyl Ether용매

실험 절차

Of the crude N,N-dimethyl-2-[methyl-(2-pyridine-4-yl-ethyl)-amino]-acetamide, 44 g are dissolved in 500 ml of glacial acetic acid and hydrogenated with 4 g of PtO2 at ambient temperature under 3 bar H2. After the catalyst has been removed by suction filtering the filtrate is evaporated down. The residue is made alkaline with 50% potassium hydroxide solution while cooling with ice and the product obtained is taken up in ether. The ether solution is dried over sodium sulphate, filtered and the solution is evaporated down. The product is left as a yellow oil. Yield: 42 g

후처리

  1. customAfter the catalyst has been removed by suction
  2. filtrationfiltering the filtrate
  3. customis evaporated down
  4. temperaturewhile cooling with ice
  5. customthe product obtained
  6. dry with materialThe ether solution is dried over sodium sulphate
  7. filtrationfiltered
  8. customthe solution is evaporated down
  9. waitThe product is left as a yellow oil

출처 및 근거

ORD 기록
ord-05c0a3db95d94e0f9fae11e3e39eced8
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420630B2

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