2-Chloroethyl isocyanate → 1-But-3-ynyl-3-(2-chloro-ethyl)-urea

HRID 1965960

반응식

HRID 1965960 반응식
[Cl:1][CH2:2][CH2:3][N:4]=[C:5]=[O:6].[CH2:7]([NH2:11])[CH2:8][C:9]#[CH:10]>C(OCC)C>[CH2:7]([NH:11][C:5]([NH:4][CH2:3][CH2:2][Cl:1])=[O:6])[CH2:8][C:9]#[CH:10]

참가 물질

4

반응물 2

HCID 160352-Chloroethyl isocyanateHCID 10034574But-3-yn-1-amine

생성물 1

HCID 597873661-But-3-ynyl-3-(2-chloro-ethyl)-urea수율 100%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Add chloroethyl isocyanate (5.25 g, 50 mmol) dropwise to a solution of but3-ynyl-amine (3.4 g, 50 mmol) (prepared by following the procedure described in Tetrahedron Lett. 1987, 43, 5145) in ethyl ether (100 mL). Stir the suspension for 30 min and filter the solid to obtain the desired intermediate (8.7 g, 100%).

후처리

  1. customprepared
  2. filtrationfilter the solid

출처 및 근거

ORD 기록
ord-7a5f8d6b5fc64492901a3aff656875a6
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420631B2

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