Hydroxyamine hydrochloride → 4-cyclohexylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde oxime

HRID 1966811노트

반응식

HRID 1966811 반응식
Cl.[NH2:2][OH:3].C([O-])(=O)C.[Na+].[CH:9]1([NH:15][C:16]2[C:21]([CH:22]=O)=[CH:20][N:19]=[C:18]3[N:24]([CH2:27][CH3:28])[N:25]=[CH:26][C:17]=23)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>C(O)C>[CH:9]1([NH:15][C:16]2[C:21]([CH:22]=[N:2][OH:3])=[CH:20][N:19]=[C:18]3[N:24]([CH2:27][CH3:28])[N:25]=[CH:26][C:17]=23)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

참가 물질

5

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 251057854-cyclohexylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde

생성물 1

HCID 866475994-cyclohexylamino-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde oxime

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Hydroxylamine hydrochloride (0.255 gm, 0.0036 mole) and sodium acetate (0.301 gm, 0.0036 mole) were added to a stirred solution of 4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde (0.250 gm, 0.0009 mole) (example 7) in ethanol. The reaction mixture was allowed to stir at room temperature for about 2 h. Ethanol was removed under reduced pressure and residue was poured in water. The title compound was then filtered and washed with water twice and finally with hexane.

후처리

  1. customEthanol was removed under reduced pressure and residue
  2. additionwas poured in water
  3. filtrationThe title compound was then filtered
  4. washwashed with water twice

출처 및 근거

ORD 기록
ord-83253dd701444a249c8a2608326454a3
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420666B2

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