Sodium Carbonate → 2-Sulfanilamido-1,3,4-thiadiazole

HRID 1966879노트

반응식

HRID 1966879 반응식
[S:1]1[CH:5]=[N:4][N:3]=[C:2]1[NH:6][S:7]([C:10]1[CH:15]=[CH:14][C:13]([NH:16]C(=O)C)=[CH:12][CH:11]=1)(=[O:9])=[O:8].C([O-])([O-])=O.[Na+].[Na+]>Cl>[NH2:16][C:13]1[CH:14]=[CH:15][C:10]([S:7]([NH:6][C:2]2[S:1][CH:5]=[N:4][N:3]=2)(=[O:9])=[O:8])=[CH:11][CH:12]=1

참가 물질

4

반응물 2

HCID 10340Sodium CarbonateHCID 694845N-(4-(N-1,3,4-thiadiazol-2-ylsulfamoyl)phenyl)acetamide

생성물 1

HCID 2347622-Sulfanilamido-1,3,4-thiadiazole수율 50%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Compound 102 (1.0 g, 3.6 mmol) was suspended in 3N HCl (10 mL) and heated to reflux for 30 min. The acidic mixture was neutralized with Na2CO3 solution. The precipitated product was collected by filtration, washed with water, and dried to give the product (450 mg, 1.8 mmol, 49%), mp 226° C. (lit1 mp 221-222° C.); 1H NMR (250 MHz, CDCl3) δ 5.95 (2, s), 6.57 (2, d, J=6.5 Hz), 7.41 (2, d, J=6.5 Hz), 8.68 (1, s), 14.03 (1, br s).

후처리

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. filtrationThe precipitated product was collected by filtration
  4. washwashed with water
  5. customdried

출처 및 근거

ORD 기록
ord-b6722aa0584d423791e09365a0dd512f
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420678B2

반응 노트

불러오는 중…