(-)-2-Aminobutyric acid → (s)-4-Ethyloxazolidine-2,5-dione

온도

50 °C

To a suspension of (2S)-2-aminobutanoic acid (10 g) and activated carbon (116 mg) in tetrahydrofuran (50 mL) was added dropwise a solution of triphosgene (10.07 g) in tetrahydrofuran (50 mL) at room temperature, and the mixture was stirred at 50° C. for 2 hr. The same experimental process was performed twice, in each of which insoluble materials were filtered off with celite, and the filtrates were combined and concentrated under reduced pressure. The residue was washed with hexane to give the title compound as a solid (yield: 22.39 g, 89%).

1. filtrationin each of which insoluble materials were filtered off with celite
2. concentrationconcentrated under reduced pressure
3. washThe residue was washed with hexane

ORD 기록

ord-23b9573340f640fea715f44301015f24

출처 데이터셋

uspto-grants-2013_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08420694B2