Pyridine → N-(4-bromo-3-chloro-2-fluorophenyl)acetamide

HRID 1967315노트

반응식

HRID 1967315 반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[C:3]=1[Cl:10].[C:11](OC(=O)C)(=[O:13])[CH3:12].N1C=CC=CC=1>C(OCC)(=O)C>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:11](=[O:13])[CH3:12])=[C:4]([F:9])[C:3]=1[Cl:10]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 27827054-Bromo-3-chloro-2-fluoroaniline

생성물 1

HCID 23273791N-(4-bromo-3-chloro-2-fluorophenyl)acetamide수율 96%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매2회

실험 절차

To a solution of 4-bromo-3-chloro-2-fluoroaniline (15.0 g) in ethyl acetate (200 mL) was added dropwise acetic anhydride (7.57 mL) at 0° C. Then, pyridine (10.8 mL) was added dropwise, and the mixture was stirred at room temperature overnight. The mixture was diluted with ethyl acetate, washed with water and saturated brine, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure. The obtained solid was washed with hexane to give the title compound as a colorless solid (yield: 17.1 g, 96%).

후처리

  1. washwashed with water and saturated brine
  2. dry with materialdried over magnesium sulfate
  3. customThe solvent was evaporated under reduced pressure
  4. washThe obtained solid was washed with hexane

출처 및 근거

ORD 기록
ord-cfa4ece443a64a96a7cf4d955a7eaaa4
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420694B2

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