Dimethylformamide dimethyl acetal → Ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-dimethylaminoacrylate

HRID 1967449

반응식

HRID 1967449 반응식
[Br:1][C:2]1[C:3]([O:18][CH3:19])=[CH:4][C:5]([O:16][CH3:17])=[C:6]([C:8](=[O:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:7]=1.CO[CH:22](OC)[N:23]([CH3:25])[CH3:24]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:3]([O:18][CH3:19])=[CH:4][C:5]([O:16][CH3:17])=[C:6]([CH:7]=1)[C:8]([C:9](=[CH:22][N:23]([CH3:25])[CH3:24])[C:10]([O:12][CH2:13][CH3:14])=[O:11])=[O:15]

참가 물질

4

반응물 2

HCID 78373Dimethylformamide dimethyl acetalHCID 25023667Ethyl 3-(5-bromo-2,4-dimethoxyphenyl)-3-oxopropionate

생성물 1

HCID 66985486Ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-dimethylaminoacrylate

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
95 °C

실험 절차

Under a nitrogen atmosphere, ethyl 3-(5-bromo-2,4-dimethoxyphenyl)-3-oxopropionate (52.8 g) obtained in Step 3 of Example 1 and N,N-dimethylformamide dimethyl acetal (44.6 g) were dissolved in toluene. The solution was stirred at 95° C. for 16 hr, and the completion of the reaction was confirmed by HPLC. The reaction mixture was cooled to room temperature to give a solution of ethyl 2-(5-bromo-2,4-dimethoxybenzoyl)-3-dimethylaminoacrylate in toluene. The reaction mixture was directly used in the next step.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature

출처 및 근거

ORD 기록
ord-a3821cee8a0a43b9ad698622ad32aaa8
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420821B2

연결된 노트

불러오는 중…