Diazald → HCID 53379981, 화합물

HRID 1967607노트

반응식

HRID 1967607 반응식
[OH-].[K+].[CH3:3]C1C=CC(S(N(N=O)C)(=O)=O)=CC=1.C(O)CO.CCOCC.[NH:26]1[C:30]2[CH:31]=[C:32]([N:35]3[CH:39]([CH:40]([CH3:42])[CH3:41])[C:38]([CH3:43])=[C:37]([OH:44])[C:36]3=[O:45])[CH:33]=[CH:34][C:29]=2[N:28]=[CH:27]1>CO>[NH:26]1[C:30]2[CH:31]=[C:32]([N:35]3[CH:39]([CH:40]([CH3:42])[CH3:41])[C:38]([CH3:43])=[C:37]([O:44][CH3:3])[C:36]3=[O:45])[CH:33]=[CH:34][C:29]=2[N:28]=[CH:27]1

참가 물질

6

반응물 4

HCID 6628DiazaldHCID 14797Potassium HydroxideHCID 21225595HCID 21225595, 화합물HCID 67387135HCID 67387135, 화합물

생성물 1

HCID 53379981HCID 53379981, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound was synthesized starting from KOH (15 eq in water), diazald (8 eq), ethylene glycol/Et2O (1/2 v/v, 30 ml), 1-(1H-Benzo[d]imidazol-6-yl)-5-isopropyl-3-hydroxy-4-methyl-1H-pyrrol-2(5H)-one (0.500 g, 1.83 mmol, 1 eq) and MeOH (10 ml); yield: 0.040 g (7.6%); MS m/z: 286.1 [M+H]+; 1H-NMR: (400 MHz, DMSO-D6) δ: 0.54 (d, 3H), 0.94-0.92 (q, 3H), 1.95 (t, 3H), 3.86 (s, 1H), 4.73 (s, 1H), 7.26-7.15 (m, 1H), 7.65-7.51 (m, 2H), 8.22 (d, 1H), 12.46 (d, 1H); HPLC (METHOD [A]): rt 8.32 min (96.64%)

후처리

  1. customThe compound was synthesized
  2. customrt 8.32 min (96.64%)

출처 및 근거

ORD 기록
ord-fac02b3b4b614ba3ad9e8f33f1f1c6c0
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420828B2

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