Phthalamide → 2-[3-(4-Fluoro-phenyl)-2-oxo-propyl]-isoindole-1,3-dione

HRID 1968437

반응식

HRID 1968437 반응식
Cl[CH2:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1.[K].[C:14]([NH2:25])(=[O:24])[C:15]1[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=1)[C:17](N)=[O:18]>CN(C=O)C>[F:11][C:8]1[CH:9]=[CH:10][C:5]([CH2:4][C:3](=[O:12])[CH2:2][N:25]2[C:14](=[O:24])[C:15]3[C:16](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:17]2=[O:18])=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6956PhthalamideHCID 5462222PotassiumHCID 135582931-Chloro-3-(4-fluorophenyl)propan-2-one

생성물 1

HCID 581269722-[3-(4-Fluoro-phenyl)-2-oxo-propyl]-isoindole-1,3-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of the product of example 23 (85 mg, 0.45 mmol) in DMF (1 mL), under a nitrogen atmosphere, was added potassium salt of phthalamide (96 mg, 0.52 mmol). The resulting mixture was stirred at room temperature for 1 h. The reaction mixture was quenched with a mixture of ice-water and filtered. The slightly pink solid was washed with water to give the titled compound as a white product (79 mg, 62% yield).

후처리

  1. customThe reaction mixture was quenched with a mixture of ice-water
  2. filtrationfiltered
  3. washThe slightly pink solid was washed with water

출처 및 근거

ORD 기록
ord-e3fb54c6f7944435b5e1bd64fba2bb64
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426405B2

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