Hydrogen Bromide → HCID 49788132, 화합물
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[CH2:1]([O:3][C:4](=[O:18])[CH:5]([C:16]#[N:17])[CH2:6][C:7]([C:9]1[CH:14]=[CH:13][N:12]=[C:11]([NH2:15])[N:10]=1)=O)[CH3:2].[BrH:19]>CCOCC.C(Cl)Cl.CC(O)=O>[CH2:1]([O:3][C:4]([C:5]1[CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][N:12]=[C:11]([NH2:15])[N:10]=2)[NH:17][C:16]=1[Br:19])=[O:18])[CH3:2]참가 물질
6
실험 절차
A solution of 4-(2-amino-pyrimidin-4-yl)-2-cyano-4-oxo-butyric acid ethyl ester (364 mg, 1.47 mmol) in anhydrous Et2O and DCM (1:1 10 mL) was added dropwise to 4.5 mL of 33% HBr in AcOH at 0° C. The mixture was left at 0° C. for 30 min and then at rt until disappearance of the starting material. The solid was filtered, washed with acetone and MeOH, neutralized with 7N NH3 in MeOH to afford 400 mg (88%) of the title compound.
후처리
- customat rt
- filtrationThe solid was filtered
- washwashed with acetone and MeOH
출처 및 근거
- ORD 기록
- ord-5bf71a72427740a0aac3d6cf4f9d826f
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08426417B2
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