2-cyano-N-cyclohexyl-N-methylacetamide → 3-Amino-N-cyclohexyl-N-methyl-propionamide

HRID 1968768노트

반응식

HRID 1968768 반응식
[C:1]([CH2:3][C:4]([N:6]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH3:7])=[O:5])#[N:2].[H][H]>[Ni].N.CO>[NH2:2][CH2:1][CH2:3][C:4]([N:6]([CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)[CH3:7])=[O:5]

참가 물질

5

반응물 2

HCID 247058332-cyano-N-cyclohexyl-N-methylacetamideHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 167934313-Amino-N-cyclohexyl-N-methyl-propionamide

시약·촉매·용매 2

HCID 935Nickel촉매HCID 21705897Ammonia methanol용매

실험 절차

A mixture of 2-cyano-N-cyclohexyl-N-methyl-acetamide (3.96 g, 0.022 mol), a known compound, (which may be prepared as disclosed in Osderie, Thomas S. et al. Journal of Medicinal Chemistry (1967), 10(2), 165-7; Osdene, Thomas S.; Santilli, Arthur A. U.S. Pat. No. 3,138,595) and Raney nickel (3 9) in NH3/MeOH (300 mL) was hydrogenated at normal pressure. After 2 equivalents of hydrogen were consumed, the catalyst was removed by filtration. The filtrate was evaporated, and toluene was added to the residue and then evaporated to yield a residue.

후처리

  1. customa known compound, (which may be prepared
  2. customthe catalyst was removed by filtration
  3. customThe filtrate was evaporated
  4. additiontoluene was added to the residue
  5. customevaporated
  6. customto yield a residue

출처 및 근거

ORD 기록
ord-cdc24b5fdd0a425a93bbe842dadd955c
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426429B2

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