N-Methylcyclohexylamine → N-cyclohexyl-N-methylethenesulfonamide
반응식
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.Cl[CH2:10][CH2:11][S:12](Cl)(=[O:14])=[O:13]>C(Cl)Cl>[CH:3]1([N:2]([CH3:1])[S:12]([CH:11]=[CH2:10])(=[O:14])=[O:13])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
A mixture of N-methylcyclohexylamine (0.048 mol) and TEA (0.053 mol) in DCM (200 mL) was cooled in an ice bath to 5° C., and then a solution of 2-chloro-ethanesulfonyl chloride (0.048 mol, 97%) in DCM (20 mL) was added dropwise. The reaction mixture was stirred for 2 hours at room temperature and then was washed with H2O. The organic layer was separated, dried (MgSO4), and filtered, and the solvent was evaporated to yield the title compound as a residue.
후처리
- washwas washed with H2O
- customThe organic layer was separated
- dry with materialdried (MgSO4)
- filtrationfiltered
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-25fa093c38a5463cab8eb9e624f518b5
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08426429B2
반응 노트
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