Hydrochloric Acid → Hydrochloric Acid

HRID 1968869노트

반응식

HRID 1968869 반응식
C([O:5][C:6]([C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[N:12]=1)=[O:7])(C)(C)C.[ClH:18]>C(Cl)Cl.O1CCOCC1>[F:17][C:13]1[N:12]=[C:11]([C@@H:9]2[CH2:10][C@H:8]2[C:6]([OH:7])=[O:5])[CH:16]=[CH:15][CH:14]=1.[ClH:18]

참가 물질

6

반응물 2

HCID 313Hydrochloric AcidHCID 67114136HCID 67114136, 화합물

생성물 2

HCID 313Hydrochloric Acid수율 79%HCID 67114406HCID 67114406, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

To a solution of trans-2-(6-fluoro-pyridin-2-yl)-cyclopropanecarboxylic acid t-butyl ester (165 mg, 0.7 mmol) in DCM (3 mL) was added HCl in dioxane (4 M, 10 mL). The resulting mixture was stirred at rt for 3 h. The mixture was then concentrated to give the desired product as HCl salt (120 mg, 79%). MS (M−H 181).

후처리

  1. concentrationThe mixture was then concentrated

출처 및 근거

ORD 기록
ord-7ea9e0fb5e794237a1f56752072c489b
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08426414B2

반응 노트

불러오는 중…