Hydrogen Bromide → 1-(1-Bromoethyl)-3-nitrobenzene

HRID 1970861노트

반응식

HRID 1970861 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10](O)[CH3:11])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[BrH:13]>C(O)(=O)C.C(Cl)Cl>[Br:13][CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[CH3:11]

참가 물질

5

반응물 2

HCID 260Hydrogen BromideHCID 223135alpha-Methyl-3-nitrobenzenemethanol

생성물 1

HCID 229178381-(1-Bromoethyl)-3-nitrobenzene

시약·촉매·용매 2

HCID 176Acetic Acid용매2회HCID 6344Dichloromethane용매

실험 절차

26.15 g (156 mmol) of 1-(3-nitrophenyl)ethanol are dissolved in 130 ml of glacial acetic acid, and 55 ml (313 mmol) of 33% HBr in glacial acetic acid are added dropwise with ice cooling. The reaction mixture is stirred at room temperature for 5 days. The mixture is subsequently diluted with 300 ml of DCM, washed with 3×200 ml of H2O and 200 ml of saturated NaHCO3 solution, dried over sodium sulfate and evaporated to dryness, and the residue is crystallised from petroleum ether.

후처리

  1. washwashed with 3×200 ml of H2O and 200 ml of saturated NaHCO3 solution
  2. dry with materialdried over sodium sulfate
  3. customevaporated to dryness
  4. customthe residue is crystallised from petroleum ether

출처 및 근거

ORD 기록
ord-26e5f94bbbb64bf9adb31032db0c486d
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431572B2

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