Ammonium Chloride → 4-(Benzyloxy)-2-fluorocyclohexanol
반응식
[CH2:1]([O:8][CH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH:11]([F:16])[CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Na+].[Cl-].[NH4+]>CO.[Cl-].[Na+].O>[CH2:1]([O:8][CH:9]1[CH2:14][CH2:13][CH:12]([OH:15])[CH:11]([F:16])[CH2:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1참가 물질
6
실험 절차
To a stirred solution of 4-(benzyloxy)-2-fluorocyclohexanone (3.8 g, 17.1 mmol) in methanol (60 mL) was added sodium borohydride (1.29 g, 34.2 mmol) at 0° C. The reaction mixture was allowed to warm to room temperature, and left to stir for 45 min. The reaction mixture was treated with ammonium chloride solution and brine, and extracted with EtOAc. The combined organics were dried (magnesium sulfate), and concentrated to afford the title compound.
후처리
- waitleft
- extractionextracted with EtOAc
- dry with materialThe combined organics were dried (magnesium sulfate)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-a8140fedebcb464498345906b84fc9d9
- 출처 데이터셋
- uspto-grants-2013_04
- 특허 번호
- US08431569B2
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