Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine → (s)-3-Bromo-n-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5h-imidazo[1,5-a][1,4]diazepine-1-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | L-tert-Leucine | HCID 164608 | — |
| 반응물 | (S)-3-bromo-8-methyl-N-(4-methyl-1-(methylamino)-1-oxopentan-2-yl)-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide | HCID 57635259 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (s)-3-Bromo-n-(1-(dimethylamino)-3,3-dimethyl-1-oxobutan-2-yl)-8-methyl-6,7,8,9-tetrahydro-5h-imidazo[1,5-a][1,4]diazepine-1-carboxamide | HCID 57635558 | — |
반응 단계
This intermediate was prepared following the synthesis of ((S)—N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-3-bromo-8-methyl-6,7,8,9-tetrahydro-5H-imidazo[1,5-a][1,4]diazepine-1-carboxamide (Intermediate 55B) by replacing Z-Leu-OH with tert-Leu-OH, and replacing methylamine hydrochloride with dimethylamine solution in THF. LCMS (+ESI) m/z 417.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08431565B2 |
| 출처 데이터셋 | uspto-grants-2013_04 |
| ORD ID | ord-d80af6178d62468cb12adbc55b8a0332 |
| 출처 메모 | uspto-grants-2013_04 |