Hydroxyamine hydrochloride → 5-n-Butylindan-1-one oxime

HRID 19716노트

반응식

HRID 19716 반응식
Cl.[NH2:2][OH:3].C([O-])(=O)C.[Na+].[CH2:9]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[C:18](=O)[CH2:17][CH2:16]2)[CH2:10][CH2:11][CH3:12]>C(O)C.O>[CH2:9]([C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[C:18](=[N:2][OH:3])[CH2:17][CH2:16]2)[CH2:10][CH2:11][CH3:12]

참가 물질

6

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 149399645-n-Butylindan-1-one

생성물 1

HCID 860040385-n-Butylindan-1-one oxime

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

Hydroxylamine hydrochloride (0.89 g, 12.8 mmol) and sodium acetate (12.8 mmol) are added to a solution of 5-n-butylindan-1-one (1.0 g, 5.31 mmol) in ethanol (30 ml) and water (3 ml). The reaction is heated to reflux for 20 minutes, then water is added and the mixture is extracted with CH2Cl2. The combined organic extracts are washed with brine, dried (MgSO4) and evaporated to afford the title compound. NMR δH 0.86 (t J 7.3 3H), 1.28 (sextet J 7.3 2H), 1.52 (quintet J 7.3 2H), 2.55 (t J 8.0 2H), 2.85-3.0 (m 4H), 7.0 (d J 8.3 1H), 7.05 (s 1H), 7.45 (d J 8.3 2H)

후처리

  1. temperatureThe reaction is heated
  2. temperatureto reflux for 20 minutes
  3. extractionthe mixture is extracted with CH2Cl2
  4. washThe combined organic extracts are washed with brine
  5. dry with materialdried (MgSO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-f90580b923b54dcea6cf2698b7828a3e
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745462B2

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