tert-Butyl acrylate → HCID 67372476, 화합물

HRID 1971909노트

반응식

HRID 1971909 반응식
Cl.Cl.[CH2:3]([C:7]1[N:8]=[N:9][C:10]([O:26][CH:27]2[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]2)=[CH:11][C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)=[CH:15][CH:14]=1)[CH2:4][CH2:5][CH3:6].[C:34]([O:38][C:39](=[O:42])[CH:40]=C)([CH3:37])([CH3:36])[CH3:35]>>[C:34]([O:38][C:39](=[O:42])[CH2:40][CH2:33][N:30]1[CH2:31][CH2:32][CH:27]([O:26][C:10]2[N:9]=[N:8][C:7]([CH2:3][CH2:4][CH2:5][CH3:6])=[C:12]([C:13]3[CH:14]=[CH:15][C:16]([O:19][CH:20]4[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]4)=[CH:17][CH:18]=3)[CH:11]=2)[CH2:28][CH2:29]1)([CH3:37])([CH3:36])[CH3:35]

참가 물질

3

반응물 2

HCID 15458tert-Butyl acrylateHCID 53373967HCID 53373967, 화합물

생성물 1

HCID 67372476HCID 67372476, 화합물

실험 절차

A mixture of 3-butyl-4-(4-cyclohexyloxy-phenyl)-6-(piperidin-4-yloxy)-pyridazine (Example 14, 0.244 mmol, 100 mg) and acrylic acid tert-butyl ester (2 mL) may be stirred at room temperature for 20 h. The organic solvent may be removed in vacuo and the residue is purified by column chromatography on silica gel using 1-2% of MeOH in DCM to give 3-{-4-[6-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazin-3-yloxy]-piperidin-1-yl}-propionic acid tert-butyl ester.

후처리

  1. customThe organic solvent may be removed in vacuo
  2. customthe residue is purified by column chromatography on silica gel using 1-2% of MeOH in DCM

출처 및 근거

ORD 기록
ord-c41986d135c647feb7029c4b6fb3ebe8
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431575B2

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