Hydrochloric Acid → 6-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide dihydrochloride

HRID 1972053노트

반응식

HRID 1972053 반응식
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@@H:4]1[CH2:8][NH:9][C:10]([C:12]1[N:13]=[N:14][C:15]([CH2:31][CH2:32][CH2:33][CH3:34])=[C:16]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:20][CH:19]=2)[CH:17]=1)=[O:11])[CH3:2].[ClH:35]>O1CCOCC1.C(Cl)Cl>[ClH:35].[ClH:35].[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@@H:4]1[CH2:8][NH:9][C:10]([C:12]1[N:13]=[N:14][C:15]([CH2:31][CH2:32][CH2:33][CH3:34])=[C:16]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)=[CH:22][CH:23]=2)[CH:17]=1)=[O:11])[CH3:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 584384156-butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide

생성물 1

HCID 673747316-Butyl-5-(4-cyclohexyloxy-phenyl)-pyridazine-3-carboxylic acid ((R)-1-ethyl-pyrrolidin-2-ylmethyl)-amide dihydrochloride

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

The amide was treated with 2 mL of 4.0 M HCl in dioxane solution in 2 mL of DCM for 1 h to provide the title compound.

출처 및 근거

ORD 기록
ord-f7093beeecc24a66a6738da40ee365d8
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08431575B2

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