Ethanol → 10,11-Dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-ol

HRID 1973103노트

반응식

HRID 1973103 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][C:11](=[O:13])[C:10]3[CH:14]=[C:15]([S:18][CH3:19])[CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:20]=1.C(O)C.[BH4-].[Na+]>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH:11]([OH:13])[C:10]3[CH:14]=[C:15]([S:18][CH3:19])[CH:16]=[CH:17][C:9]=3[S:8][C:7]=2[CH:20]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 4311764Sodium borohydrideHCID 128221953-methoxy-8-methylthio-dibenzo[b,f]thiepin-10(11H)-one

생성물 1

HCID 1282219810,11-Dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-ol

시약·촉매·용매 1

HCID 962Water용매

실험 절차

17.8 G. of 3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10(11H)-one are suspended in 150 ml. of ethanol and treated with 3.8 g. of sodium borohydride. The mixture is stirred for 90 minutes. Then, it is treated with water and extracted with ether. The organic phase is washed with water, dried over magnesium sulfate, evaporated, and there is obtained 10,11-dihydro-3-methoxy-8-methylthio-dibenzo[b,f]thiepin-10-ol having a melting point of 122°-124° C.

후처리

  1. extractionextracted with ether
  2. washThe organic phase is washed with water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-c1dec78aba7e49dda5666e2b32b88a19
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03996229

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