Hydroxyamine hydrochloride → (3aS,6aR)-2-butylhexahydrocyclopenta[c]pyrrol-5-one oxime
반응식
[CH2:1]([N:5]1[CH2:9][C@H:8]2[CH2:10][C:11](=O)[CH2:12][C@H:7]2[CH2:6]1)[CH2:2][CH2:3][CH3:4].Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+]>C(O)C.O>[CH2:1]([N:5]1[CH2:9][C@H:8]2[CH2:10][C:11](=[N:15][OH:16])[CH2:12][C@H:7]2[CH2:6]1)[CH2:2][CH2:3][CH3:4]참가 물질
6
실험 절차
A suspension of (3aS,6aR)-2-butylhexahydrocyclopenta[c]pyrrol-5-one (0.467 g, 2.58 mmol), hydroxylamine hydrochloride (0.430 g, 6.19 mmol) and sodium acetate (0.842 g, 6.19 mmol) in ethanol (21 ml) and water (7 ml) is heated to reflux for 1 hour. The ethanol is evaporated and the residue partitioned between saturated aqueous NaHCO3 and EtOAc. The organic phase is washed with brine, dried (MgSO4) and evaporated to afford (3aS,6aR)-2-butylhexahydrocyclopenta[c]pyrrol-5-one oxime, MH+197.
후처리
- temperatureis heated
- temperatureto reflux for 1 hour
- customThe ethanol is evaporated
- customthe residue partitioned between saturated aqueous NaHCO3 and EtOAc
- washThe organic phase is washed with brine
- dry with materialdried (MgSO4)
- customevaporated
출처 및 근거
- ORD 기록
- ord-b5a74cdf84d84e83bcf5cdc7da1404a2
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745462B2
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