Sodium Hydroxide → 2-amino-4,5-dimethylthiophene-3-carboxylic acid

HRID 1973411노트

반응식

HRID 1973411 반응식
[NH2:1][C:2]1[S:3][C:4]([CH3:13])=[C:5]([CH3:12])[C:6]=1[C:7]([O:9]CC)=[O:8].[OH-].[Na+]>C(O)C.O.C(O)(=O)C>[NH2:1][C:2]1[S:3][C:4]([CH3:13])=[C:5]([CH3:12])[C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

6

반응물 2

HCID 14798Sodium HydroxideHCID 78536Ethyl 2-amino-4,5-dimethyl3-thenoate

생성물 1

HCID 37266372-amino-4,5-dimethylthiophene-3-carboxylic acid

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 15 parts of ethyl 2-amino-4,5-dimethylthiophene-3-carboxylate and 75 parts by volume of 2N solution of sodium hydroxide in 50% aqueous ethanol is refluxed for 2.5 hours. After cooling the solution is diluted with 75 parts by volume of water and neutralized with acetic acid under cooling with ice. The resulting precipitate is collected by filtration to give 2-amino-4,5-dimethylthiophene-3-carboxylic acid as crystals. Recrystallization from chloroform with charcoal gives colorless needles melting at 136°-138° C (decomposition).

후처리

  1. temperatureis refluxed for 2.5 hours
  2. temperatureAfter cooling the solution
  3. temperatureunder cooling with ice
  4. filtrationThe resulting precipitate is collected by filtration

출처 및 근거

ORD 기록
ord-6688fa80f3c548d984986a4d1100f606
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03997545

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