Potassium → N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide

HRID 1973448

반응식

HRID 1973448 반응식
[CH:1]12[C:15](=[O:16])[NH:14][C:13](=[O:17])[CH:2]1[C:3]1[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]2=3)[CH:6]=[CH:5][CH:4]=1.[K].S(C1C=CC(C)=CC=1)(O)(=O)=O.O[CH2:31][CH2:32][N:33]1[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][N:35]=[C:34]1[CH3:41]>O>[CH3:41][C:34]1[N:33]([CH2:32][CH2:31][N:14]2[C:13](=[O:17])[CH:2]3[C:3]4[C:12]5[C:7](=[CH:8][CH:9]=[CH:10][C:11]=5[CH:1]3[C:15]2=[O:16])[CH:6]=[CH:5][CH:4]=4)[C:37]([N+:38]([O-:40])=[O:39])=[CH:36][N:35]=1

참가 물질

5

반응물 3

HCID 5462222PotassiumHCID 21491653Acenaphthene-1,2-dicarboximideHCID 867342581-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole tosylate

생성물 1

HCID 21491671N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Acenaphthene-1,2-dicarboximide is converted to the potassium salt and reacted with 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole tosylate according to the procedure described in Example 13. The crude reaction mixture is cooled and diluted with water, and then extracted with toluene. The solvent is evaporated from the toluene extract and the residue recrystallized from ethanol to give N-[2-(2-methyl-5-nitro-1-imidazolyl)ethyl]-acenaphthene-1,2-dicarboximide melting at about 183°-185° C.

후처리

  1. customThe crude reaction mixture
  2. temperatureis cooled
  3. extractionextracted with toluene
  4. customThe solvent is evaporated from the toluene
  5. extractionextract
  6. customthe residue recrystallized from ethanol

출처 및 근거

ORD 기록
ord-89f21b68d4a7411f94b4a050c9f0a229
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03997572

연결된 노트

불러오는 중…