1,2-Ethanediamine, N1,N1-bis(1-methylethyl)- → HCID 23456456, 화합물

HRID 1973461노트

반응식

HRID 1973461 반응식
[CH:1]([N:4]([CH2:8][CH2:9][NH2:10])[CH:5]([CH3:7])[CH3:6])([CH3:3])[CH3:2].[OH:11][C:12]1[CH:27]=[CH:26][C:15]([C:16](=O)[CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][C:19]2=O)=[CH:14][CH:13]=1>C(O)(=O)C.O.Cl>[CH:1]([N:4]([CH:5]([CH3:7])[CH3:6])[CH2:8][CH2:9][N:10]1[C:19]2[CH2:20][CH2:21][CH2:22][CH2:23][C:18]=2[CH:17]=[C:16]1[C:15]1[CH:14]=[CH:13][C:12]([OH:11])=[CH:27][CH:26]=1)([CH3:3])[CH3:2]

참가 물질

6

반응물 2

HCID 84591,2-Ethanediamine, N1,N1-bis(1-methylethyl)-HCID 12270333Cyclohexanone, 2-[2-(4-hydroxyphenyl)-2-oxoethyl]-

생성물 1

HCID 23456456HCID 23456456, 화합물

시약·촉매·용매 3

HCID 176Acetic Acid용매HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

A solution of 5.77 g (0.04 mole) of diisopropylaminoethylamine and 9.3 g (0.04 mole) of 2-(p-hydroxyphenacyl) cyclohexanone in glacial acetic acid is refluxed under nitrogen for 14 hours, then cooled to ambient temperature and diluted with water and dilute hydrochloric acid. The aqueous solution is washed with ether, basified with 10% sodium carbonate and extracted with ether. After drying the ether solution over magnesium sulfate, the ether is removed to give a pale yellow solid. The solid is recrystallized from an ether-petroleum ether mixture to give pale yellow crystals of 1-(2-diisopropylaminoethyl)-2-(p-hydroxyphenyl)-4,5,6,7-tetrahydroindole as pale yellow crystals, m.p. 112°-114.5° C.

후처리

  1. washThe aqueous solution is washed with ether
  2. extractionextracted with ether
  3. dry with materialAfter drying the ether solution over magnesium sulfate
  4. customthe ether is removed
  5. customto give a pale yellow solid
  6. customThe solid is recrystallized from an ether-petroleum ether mixture

출처 및 근거

ORD 기록
ord-6088b8d70ba448e280fdd279b831cbeb
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03997557

반응 노트

불러오는 중…