Potassium thiocyanate → 1-(alpha-Thiocyanoacetyl) azetidine

HRID 1973635노트

반응식

HRID 1973635 반응식
Cl[CH2:2][C:3]([N:5]1[CH2:8][CH2:7][CH2:6]1)=[O:4].[S-:9][C:10]#[N:11].[K+]>C(O)C>[S:9]([CH2:2][C:3]([N:5]1[CH2:8][CH2:7][CH2:6]1)=[O:4])[C:10]#[N:11]

참가 물질

4

반응물 2

HCID 516872Potassium thiocyanateHCID 25431591-(Azetidin-1-yl)-2-chloroethan-1-one

생성물 1

HCID 536707741-(alpha-Thiocyanoacetyl) azetidine

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

1-(α-Chloroacetyl) azetidine (13 grams; 0.1 mol), potassium thiocyanate (18 grams; 0.18 mol) and ethanol (100 ml) are charged into a glass reaction flask equipped with stirrer and reflux condenser. The reaction mixture is then heated at reflux, with stirring, for a period of about 4 hours. After this time the reaction mixture is cooled and filtered. The filtrate is then stripped of ethanol leaving a residue. The residue is extracted twice with hot benzene and the two benzene extracts are combined. The benzene extract is then evaporated under reduced pressure to yield 1-(α-thiocyanoacetyl) azetidine as a residue.

후처리

  1. customequipped with stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction mixture is then heated
  4. temperatureat reflux
  5. temperatureAfter this time the reaction mixture is cooled
  6. filtrationfiltered
  7. extractionThe residue is extracted twice with hot benzene
  8. extractionThe benzene extract
  9. customis then evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-d16fa4394c0e450db58adfab8008724e
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03998808

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