Benzaldehyde → HCID 86734277, 화합물

HRID 1973677

반응식

HRID 1973677 반응식
[C:1]([NH:5][CH2:6][C@H:7]([OH:10])CO)([CH3:4])([CH3:3])[CH3:2].[CH:11](=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH:19]1C=CC=CC=1>O>[C:1]([N:5]1[CH2:6][CH:7]([OH:10])[O:18][C@@:11]1([CH3:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 3

HCID 240BenzaldehydeHCID 241BenzeneHCID 2733671(S)-3-(tert-Butylamino)propane-1,2-diol

생성물 1

HCID 86734277HCID 86734277, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

22 g of (S)-1-tert.butylamino-2,3-dihydroxypropane, 20.7 g of benzaldehyde and 46 cc of benzene are heated at reflux in a water separator for 16 hours. The benzene and benzaldehyde are removed by distillation and the residue is distilled in a high vacuum. (S)-3-tert. butyl-5-hydroxy-methyl-2-phenyloxazolidine is obtained as yellowish oil (B.P. 110°-125° at 0.01 mm of Hg); [α]20546 = 17.8° (c = 1.99; chloroform).

후처리

  1. customThe benzene and benzaldehyde are removed by distillation
  2. distillationthe residue is distilled in a high vacuum

출처 및 근거

ORD 기록
ord-87237c1e6f21415095e22b72680f230e
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03998835

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