Water → 3alpha-Acetoxy-5alpha-pregnane-11,20-dione

HRID 1973740노트

반응식

HRID 1973740 반응식
[OH:1][C@@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C:17](=[O:23])[CH2:16][C@@:15]2([CH3:24])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1.[C:25](OC(=O)C)(=[O:27])[CH3:26].O>N1C=CC=CC=1>[C:25]([O:1][C@@H:2]1[CH2:21][CH2:20][C@@:19]2([CH3:22])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:18]2[C:17](=[O:23])[CH2:16][C@@:15]2([CH3:24])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:14])[CH3:13])[CH2:3]1)(=[O:27])[CH3:26]

참가 물질

5

반응물 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 104845Alphaxalone

생성물 1

HCID 118727973alpha-Acetoxy-5alpha-pregnane-11,20-dione

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A solution of 3α-hydroxy-5α-pregnane-11,20-dione (1 g) in pyridine (ca 5 ml) was treated with acetic anhydride (2.5 ml) and allowed to stand overnight. The reaction mixture was poured into water and the solid collected by filtration and dried to give the title compound m.p. 150°-151°.

후처리

  1. filtrationthe solid collected by filtration
  2. customdried

출처 및 근거

ORD 기록
ord-25e966eb05ea4922a5fa0331b4c1c324
출처 데이터셋
uspto-grants-1976_12
특허 번호
US03998829

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