Acetic Anhydride → Nicotinamide

HRID 1974090노트

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HRID 1974090 반응식
[N+](C1C=CC=CC=1C=O)([O-])=O.C([N:14](CC)[C:15](=[O:23])[C:16]1[CH:21]=[CH:20][C:19](C)=[N:18][CH:17]=1)C.C(OC(=O)C)(=O)C.C(N(CC)C(=O)C1C=CC(C=CC2C=CC=CC=2[N+]([O-])=O)=NC=1)C>>[C:15]([NH2:14])(=[O:23])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1

참가 물질

5

반응물 4

HCID 7918Acetic AnhydrideHCID 111012-NitrobenzaldehydeHCID 10081297N,N-diethyl-6-methylnicotinamideHCID 53931032HCID 53931032, 화합물

생성물 1

HCID 936Nicotinamide

실험 절차

Reaction of o-nitrobenzaldehyde (41.7 g., 0.276 mole) with N,N-diethyl-6-methylnicotinamide (53.1 g., 0.276 mole) in the presence of acetic anhydride (56.3 g., 0.552 mole) according to the method of L. Horwitz, J. Org. Chem., 21, 1039 (1956) provides 67.4 g. (75%) of N,N-diethyl-6-(o-nitrostyryl)-nicotinamide. Crystallization from acetonitrile affords the analytically pure nicotinamide having a melting point of 145°-147° C. (corr.).

후처리

  1. custom, 21, 1039 (1956) provides 67.4 g
  2. customCrystallization from acetonitrile

출처 및 근거

ORD 기록
ord-f6118c1f7c4f48f6a0fb2ad8b61d79b9
출처 데이터셋
uspto-grants-1976_12
특허 번호
US04000143

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