Sodium borohydride → cis-3-Azido-2-hydroxymethyl-4-oxoazetidine

HRID 1974186노트

반응식

HRID 1974186 반응식
[N:1]([C@H:4]1[C:7](=[O:8])[NH:6][C@H:5]1[C:9](OC)=[O:10])=[N+:2]=[N-:3].[BH4-].[Na+]>>[N:1]([C@H:4]1[C:7](=[O:8])[NH:6][C@H:5]1[CH2:9][OH:10])=[N+:2]=[N-:3]

참가 물질

3

반응물 2

HCID 4311764Sodium borohydrideHCID 13566680Methyl (2R,3R)-3-azido-4-oxoazetidine-2-carboxylate

생성물 1

HCID 86734333cis-3-Azido-2-hydroxymethyl-4-oxoazetidine

실험 절차

Methyl cis-3-azido-4-oxoazetidine-2-carboxylate was reduced with sodium borohydride as described in Preparation 3 and the product was chromatographed on silica gel with ethyl acetate as eluant to give cis-3-azido-2-hydroxymethyl-4-oxoazetidine.

후처리

  1. customas described in Preparation 3
  2. customthe product was chromatographed on silica gel with ethyl acetate as eluant

출처 및 근거

ORD 기록
ord-8400b16c156646f5ba1853ca1cf6be9d
출처 데이터셋
uspto-grants-1976_12
특허 번호
US04000154

반응 노트

불러오는 중…